Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome.
نویسندگان
چکیده
Hirsutism is a common and distressing symptom frequently encountered in women with polycystic ovary syndrome (PCOS), who also show relative insulin resistance. The aim of this trial, in which hirsutism was the primary end point, was to compare the efficacy of the oral antihyperglycemic medication metformin with that of an established treatment, combined ethinyl estradiol and cyproterone acetate. Patients (n = 52) were randomized to receive either metformin (500 mg, three times daily) or Dianette (ethinyl estradiol, 35 micro g; cyproterone acetate, 2 mg) treatment for 12 months, with assessments before treatment, at 6 months, and at 12 months. Both objective and subjective methods of evaluating hirsutism were used, and in addition, patient perceptions were examined. The results show that metformin is potentially an effective treatment for moderate to severe hirsutism in women with PCOS. They also suggest that in some respects (Ferriman-Gallwey score and patient self-assessment), it is more efficacious than the standard treatment (Dianette). The objective evaluation of hair diameter reduction showed that both treatments were moderately effective at multiple anatomical sites. Dianette treatment was responsible for profound suppression of androgen activity, in contrast to metformin, which induced negligible change. However, metformin did reduce markers of insulin resistance. The data suggest that hirsutism may be effectively treated by reducing hyperinsulinemia.
منابع مشابه
P-85: Effect of Metformin on Anti-Mullerian Hormone (AMH) Level in Women with Infertility and Polycystic Ovary Syndrome
Background Women with PCOS have increased AMH levels due to accumulated preantral and small antral in follicles. Ovulation improvement following decrease in levels of AMH could accure in these patients. The purpose of this study was to evaluate the effect of metformin on anti-Mullerian hormone levels in women with polycystic ovary syndrome and infertility MaterialsAndMethods This randomized cli...
متن کاملHerbal Medicine in the Treatment of Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is a hormonal disorder that affects between 5 - 10% of women who are of reproductive age. The most common symptoms of PCOS are obesity/difficulty losing weight, acne, amenorrhea (absence of menstrual cycles), irregular menstrual cycles, hirsutism (increased growth of corporal hair), insulin resistance, and high cholesterol. One of the treatments for PCOS is the ...
متن کاملDrug treatments for polycystic ovary syndrome.
Polycystic ovary syndrome is a condition present in approximately 5 to 10 percent of women of childbearing age. Diagnosis can be difficult because the signs and symptoms can be subtle and varied. These may include hirsutism, infertility, menstrual irregularities, and biochemical abnormalities, most notably insulin resistance. Treatment should target specific manifestations and individualized pa...
متن کاملP-191: Association of STK11 Gene Polymorphisms with Methformin Treatment in Patients with Polycystic Ovary Syndrome
Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical endocrinology and metabolism
دوره 88 9 شماره
صفحات -
تاریخ انتشار 2003